Trans-Resveratrol: A Potent Antioxidant and Anti-Aging Supplement


When it comes to aging, many people seek ways to slow down the process and maintain their youthful appearance and vitality. One supplement that has gained attention in recent years is Trans-Resveratrol.

In this article, we will explore what Trans-Resveratrol is, its sources, and its potential anti-aging benefits.

What is Trans-Resveratrol

Trans-Resveratrol is a natural compound found in several plants, including grapes, blueberries, and peanuts.

It is a type of polyphenol and has potent antioxidant and anti-inflammatory properties.

Trans-Resveratrol has gained significant attention in recent years due to its potential role in slowing down the aging process and promoting overall health.

Doctors like David Sinclair are huge advocates of resveratrol for anti-aging. Here’s a short video from our YouTube channel.

Origins of Trans-Resveratrol

The discovery of Trans-Resveratrol dates back to 1939 when a Japanese researcher, Dr. Michio Takaoka, isolated it from the roots of a medicinal plant called Veratrum grandiflorum. [1]

However, it was not until the 1990s that the potential health benefits of Trans-Resveratrol were recognized.

It was found to be present in red wine, which led to the “French Paradox” – the observation that the French had lower rates of heart disease despite a high-fat diet, attributed to their regular consumption of red wine.

Veratrum grandiflorum / Source

Chemical Structure and Natural Sources

Trans-Resveratrol has a chemical structure that consists of two phenol rings connected by a double bond. It is a type of stilbene and has the molecular formula C14H12O3. [2]

Trans-Resveratrol is present in several plants, including grapes, blueberries, peanuts, and Japanese knotweed. It is most abundant in the skin of grapes and berries.

The concentration of Trans-Resveratrol in these plants is influenced by environmental factors such as light, temperature, and stress.

Nevertheless, here’s a table that shows the foods with the highest content in resveratrol.

RankFood SourceResveratrol Content (per 100 grams)
1Red Wine0.1 – 14.3 mg
2Red Grape Juice0.17 – 1.89 mg
3Peanuts0.01 – 0.26 mg
4Fresh Grapes0.24 – 1.25 mg
5Pistachios0.03 mg
6Peanut Butter0.04 – 0.13 mg
7Cocoa Powder0.1 – 0.25 mg
8Dark Chocolate0.35 – 1.85 mg
9Blueberries0.16 – 0.62 mg
10Cranberries0.15 – 0.26 mg

*Please note that the resveratrol content in these food sources can vary depending on factors such as the variety, growing conditions, and processing methods

Trans-Resveratrol Vs Resveratrol

Trans-resveratrol and resveratrol are both forms of resveratrol. However, they differ in their molecular structures.

Trans-resveratrol is the biologically active form of resveratrol and has a trans molecular configuration, while resveratrol can exist in both trans and cis configurations.

The trans configuration is more stable and is the preferred form for supplements.Trans-Resveratrol is believed to be more effective in promoting health and longevity.

The structural formula of trans resveratrol and cis resveratrol
The structural formula of trans resveratrol and cis resveratrol / Source: ResearchGate

Trans Resveratrol Benefits

Packed With Antioxidants

Trans-Resveratrol has potent antioxidant properties and can neutralize harmful free radicals in the body. [3]

Free radicals are highly reactive molecules that can damage cells and DNA, leading to aging and various diseases. By scavenging these free radicals, Trans-Resveratrol helps protect cells from oxidative stress and promotes overall health.

Activates Sirtuins

Sirtuins are a group of proteins that play a crucial role in aging and metabolism. [4]

Trans-Resveratrol activates Sirtuins, which can help delay aging and improve metabolic function. [5]

Sirtuins also regulate cellular processes such as DNA repair, gene expression, and inflammation, making them a promising target for anti-aging therapies. [6]

Modulates Inflammatory Pathways

Inflammation is a natural response of the body to injury or infection. However, chronic inflammation can contribute to various diseases, including cancer, heart disease, and Alzheimer’s disease.

Trans-Resveratrol can modulate inflammatory pathways and reduce inflammation, thus preventing or mitigating the development of these diseases. [7]

Boosts Cognitive Function

Trans-resveratrol has been shown to improve cognitive function and protect against neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. [8]

Supports Heart Health

Trans-resveratrol has been shown to improve cardiovascular health by reducing blood pressure, lowering LDL cholesterol levels, and improving endothelial function. [9]

Feel free to check an earlier article we published on Resveratrol Benefits for Heart Health

Promotes Healthy Cell Growth

Trans-resveratrol has been shown to promote healthy cell growth and inhibit the growth of cancer cells. It may also help prevent the formation of new blood vessels that feed tumors. [10]

Supports Healthy Metabolism

Supporting healthy metabolism and reducing the risk of metabolic disorders such as diabetes and obesity. Trans-resveratrol has been shown to improve insulin sensitivity and glucose metabolism, which may help reduce the risk of type 2 diabetes and obesity. [11]

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Trans Resveratrol And Anti-Aging

Resveratrol has been touted as a powerful anti-aging supplement. While there is still much research to be done, some studies have suggested that resveratrol may help slow down the aging process by:

  • Protecting the skin against damage caused by UV radiation and environmental pollutants: Resveratrol has been shown to protect the skin against UV radiation and other environmental pollutants that can cause premature aging and skin damage.
  • Reducing inflammation, which is associated with the aging process: Chronic inflammation is associated with many chronic diseases and can accelerate the aging process. Resveratrol has been shown to reduce inflammation in the body and may help slow down the aging process as a result.
  • Activation of sirtuins: As mentioned earlier, sirtuins are a family of proteins that play a role in aging and metabolism. Resveratrol has been shown to activate sirtuins, which may help slow down the aging process and improve metabolic function.
  • Improve Mitochondria function: Additionally, trans-resveratrol has been found to improve the function of mitochondria, which are the energy-producing organelles in cells. [12] As we age, the function of our mitochondria declines, which can contribute to the aging process. Trans-resveratrol has been shown to improve mitochondrial function, which may help to slow down the aging process.

Dosage and Side Effects

The recommended dosage of trans-resveratrol varies depending on the specific supplement and the reason for taking it. Generally, doses range from 100 mg to 500 mg per day, taken with food.

Trans-resveratrol absorption

Several factors can enhance the absorption of trans-resveratrol, allowing the body to better utilize its potential health benefits.

Firstly, consuming trans-resveratrol with fatty foods can enhance its absorption, as it is a fat-soluble compound. This means that consuming trans-resveratrol with a meal that contains healthy fats, such as avocado or olive oil, can help increase its bioavailability.

Secondly, using supplements that contain trans-resveratrol in combination with piperine, a compound found in black pepper, can also enhance its absorption. Piperine has been shown to inhibit certain enzymes in the liver that break down trans-resveratrol, allowing more of the compound to be absorbed into the bloodstream. [13]

Thirdly, the form of trans-resveratrol can also impact its absorption. Trans-resveratrol supplements in powder or liquid form have been shown to have higher bioavailability compared to capsules or tablets.

Lastly, the timing of consumption may also affect absorption. Consuming trans-resveratrol in smaller doses throughout the day may be more effective than consuming a large dose all at once. This is because the body can only absorb so much of the compound at one time, and spreading out the dose may allow for better absorption and utilization.

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Potential Side Effects

Trans-resveratrol is generally considered safe when taken at recommended doses. However, high doses may cause gastrointestinal symptoms such as diarrhea and nausea.

It may also interact with blood-thinning medications and increase the risk of bleeding. Therefore, individuals taking these medications should consult with their healthcare provider before taking trans-resveratrol.

Resveratrol and NMN

Many anti-aging doctors and researchers (like Dr. David Sinclair) believe that combining resveratrol with another supplement called nicotinamide mononucleotide (NMN) may provide even greater anti-aging benefits.

NMN is a molecule that is involved in the production of a compound called nicotinamide adenine dinucleotide (NAD+), which plays a critical role in energy metabolism and DNA repair.

Both resveratrol and NMN have been shown to activate sirtuins, which are proteins that play a role in aging and metabolism. Additionally, NMN has been shown to increase NAD+ levels, which decline with age. By increasing NAD+ levels, NMN may help to improve energy metabolism and DNA repair, which can help to slow down the aging process.

Combining resveratrol with NMN may provide even greater anti-aging benefits by activating sirtuins and increasing NAD+ levels. However, more research is needed to determine the optimal dosages and potential side effects of this combination.

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  • Trans-resveratrol is a natural compound found in grapes, red wine, and other plant-based foods. It has been shown to have a wide range of health benefits, including its potential role in slowing down the aging process.
  • Trans-resveratrol works by activating sirtuins, which are proteins that play a role in aging and metabolism. It also acts as an antioxidant and anti-inflammatory agent, which may help to protect against age-related diseases.
  • While trans-resveratrol is generally considered safe when taken at recommended doses, it may interact with certain medications and cause gastrointestinal symptoms at high doses. Therefore, individuals should consult with their healthcare provider before taking trans-resveratrol.

Overall, the potential anti-aging benefits of trans-resveratrol are promising, but more research is needed to fully understand its mechanisms of action and long-term effects. However, it may hold great promise as a therapeutic agent for age-related diseases and to improve overall health and longevity.

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