Best Male Fertility Supplements: 6 Picks Ranked by Trial Doses and Real Cost New

I checked each label against the doses used in clinical trials, so you skip underdosed bottles and pick one worth 90 days.

My first semen analysis came back at 31% progressive motility, meaning 31 of every 100 sperm swam forward. The urologist said, “Try an antioxidant for three months and we’ll retest.” I searched Amazon and got hundreds of bottles making the same claims.

So I read labels instead of marketing. A Cleveland Clinic team graded 90 ingredients from 17 popular male fertility products and found positive evidence for only 17% of them ^[1].

Another review found that 19 of 21 commercial products dosed key ingredients below the minimum effective amount ^[13]. That second number surprised me most.

Below are 6 picks scored on label dose versus trial dose, 90-day cost, pills per day, and published evidence.

Summary of recommendations

• Best overall: SIRE I
• Best for folate and choline: Bird&Be Male Fertility Power Pack
• Best all-in-one multivitamin: Fairhaven Health FH PRO for Men
• Best budget pick: Theralogix ConceptionXR Reproductive Health
• Best pill-free formula: Proxeed Plus
• Best single-ingredient add-on: Thorne CoQ10

Best Overall

SIRE I Fertility Support for Men

For men who want CoQ10, NAC and L-carnitine in one bottle with every dose listed for $49.95 a month.

SIRE I packs 14 ingredients into 3 daily capsules. CoQ10 comes in at 250 mg, above the 200 mg dose tested in the 2009 Balercia trial. NAC matches the 600 mg used in the 2019 Jannatifar study. L-carnitine tartrate sits at 500 mg, well below the 2 g Lenzi tested, so you get less carnitine than the trials used. A subscription costs $49.95 a month, about $1.67 a day, or you can buy one bottle for $64.95. No trial has tested the finished formula, and the gelatin capsule rules it out for vegetarians. If you want a formula with its own clinical trial, look at FH Pro for Men.

Check Price

How we picked

I started with the 34 brands in the 2023 de Ligny review, which checked labels against recommended intakes and published studies ^[3].

I added newer direct-to-consumer formulas, dropped any product that hid doses in a proprietary blend (a mix that lists only a total weight), and kept 6.

Dose match against trial doses for CoQ10, NAC, L-carnitine, zinc, selenium, and vitamins C and E counted for 35% of each score. Published evidence counted for 25%. Safety counted for 15%, and any ingredient above its upper limit (the highest daily intake unlikely to cause harm) lost points ^[10].

Cost per 90 days counted for 15%, and label transparency for 10%. I read every Supplement Facts panel and checked prices in November 2026. I did not lab test any product.

SIRE I: Best overall

SIRE I is a three-capsule daily formula built on CoQ10, NAC, and L-carnitine, with every amount printed on the label ^[16].

It ranks first because two of its three anchor ingredients sit at trial doses for $1.67 a day ^[16]. It suits men with a borderline semen analysis who want one bottle.

Read the full SIRE I label and current price

Ingredient analysis

CoQ10 (as ubiquinone), 250 mg. CoQ10 helps the mitochondria (energy-producing parts) in the sperm midpiece, the section behind the head, make ATP, the fuel that drives the tail. Balercia and colleagues gave 60 men with poor motility 200 mg a day or a placebo (a dummy pill) for 6 months, and motility rose in the treated group ^[4]. Evidence level is a human randomized trial.

N-acetyl cysteine (NAC), 600 mg. NAC supplies cysteine, which your body uses to build glutathione. Glutathione = your main internal antioxidant. In 50 infertile men, 600 mg a day for 3 months raised count and motility and lowered DNA fragmentation, the share of sperm with broken DNA ^[5]. The study had no placebo group, so treat it as preliminary.

L-carnitine tartrate, 500 mg. Carnitine carries fats into mitochondria so sperm can burn them for energy. The tartrate salt is about 68% L-carnitine by weight, so 500 mg delivers roughly 340 mg. Lenzi’s placebo-controlled trial used 2 g of L-carnitine plus 1 g of acetyl-L-carnitine (a related form) daily for 6 months ^[6]. SIRE gives you about 17% of that carnitine dose. (Ed. note, this is the formula’s weakest point. With very low motility, ask your urologist about extra carnitine.)

Lycopene 24 mg, alpha-lipoic acid 250 mg, and ashwagandha 250 mg. Ashwagandha raised sperm count by 167% in a study that used 675 mg a day ^[14], about 2.7 times SIRE’s dose. Lycopene is a red plant pigment with antioxidant activity ^[15], but lycopene and alpha-lipoic acid have thinner sperm data, so count them as preliminary.

Zinc glycinate 24 mg and selenium glycinate 120 mcg (micrograms) sit below the adult upper limits of 40 mg and 400 mcg ^[10][11]. Vitamin A totals 6.45 mg, or 716% of the daily value, from retinyl palmitate (preformed vitamin A) and beta-carotene (a plant form your body converts as needed) ^[16]. The upper limit for preformed vitamin A is 3,000 mcg ^[12]. SIRE does not publish the split, so ASK the brand if you take other vitamin A sources.

Pricing

As of November 2026, a subscription costs $49.95 a month for 30 servings, or $1.67 per serving ^[16]. A one-time bottle costs $64.95, and a one-time three-pack costs $164.95, or $1.83 per serving ^[16]. A 90-day cycle costs $149.85 on subscription. The first subscription bottle carries a 30-day money-back guarantee, even if opened. The refund covers the bottle price but not shipping or renewals ^[16].

Shipping

Subscriptions ship free to the contiguous US. Orders leave in 1 to 3 business days and arrive 3 to 10 business days later. Alaska, Hawaii, and US territories pay the rates shown at checkout ^[16].

Where to buy

SIRE sells through its official store. Check SIRE I pricing on the official store.

Want more folate and choline? The next pick covers both.

Bird&Be Male Fertility Power Pack: Best for folate and choline

Bird&Be sells its Male Fertility Power Pack as a monthly set of daily supplements built around folate, choline, CoQ10, and NAC ^[17]. It ranks second because it covers choline, which most male formulas skip, at a price close to SIRE ^[17]. It fits men who want methylated folate in their daily routine.

See the Bird&Be Power Pack label

Ingredient analysis

Folate (as 5-methyltetrahydrofolate and folic acid), 1 mg, or 417% of the daily value ^[17]. Folate helps your body copy DNA when it builds new sperm cells. Methylfolate = folate in the active form your body uses without conversion. Folate alone has a weak record. A trial of 2,370 couples found that 5 mg of folic acid plus 30 mg of zinc did not raise live births, at 34% versus 35% on placebo ^[9].

Choline (as choline bitartrate), 100 mg, or 18% of the daily value ^[17]. Bird&Be links choline to sperm membranes and DNA methylation and suggests eating 2 to 3 eggs a day to reach a full dose ^[17]. DNA methylation = chemical tags that switch genes on and off. I found no randomized male fertility trial on choline, so rate it as preliminary.

CoQ10, NAC, and L-carnitine. Bird&Be lists these in its male fertility line and sells a CoQ10 upgrade pack ^[17]. I could not confirm per-serving amounts on the product page in November 2026. Compare the Supplement Facts with 200 mg of CoQ10 ^[4], 600 mg of NAC ^[5], and 2 g of L-carnitine ^[6] before you buy. If the numbers fall short, you are paying for a label claim.

Calcium (as calcium citrate), 50 mg, or 4% of the daily value ^[17]. Calcium helps sperm signal and swim, but 50 mg adds little.

“Isn’t 52.2% proof?” Not yet. Bird&Be advertises a 52.2% motility gain in 3 months for its Power plus CoQ10 pack ^[17]. I could not find a peer-reviewed, placebo-controlled trial behind that figure, so treat it as brand data.

Pricing

As of November 2026, the pack costs $56.70 for a 30-day supply, or $1.89 per day ^[17]. A 90-day cycle costs $170.10. The product page does not list guarantee terms, so ask support before you order.

Shipping

The product page I reviewed does not state shipping cost, delivery window, or countries served. It carries both FDA and Health Canada disclaimers, which suggests Canadian sales, but confirm in your cart.

Where to buy

Buy from the official Bird&Be store for subscription options, or find the pack on Amazon. Compare Bird&Be pack options.

If you want a single bottle with a published study on its exact formula, FH PRO is next.

Fairhaven Health FH PRO for Men: Best all-in-one multivitamin

FH PRO for Men is a six-capsule fertility multivitamin with trial-level L-carnitine and CoQ10 ^[7]. Researchers tested this exact formula in 148 infertile men over 3 months ^[7]. It suits men with an abnormal semen analysis who want one product that also covers basic vitamins.

Review the FH PRO for Men formula

Ingredient analysis

The study formula delivered, per six capsules, 2,000 mg of L-carnitine tartrate, 200 mg of CoQ10, 200 mg of NAC, 350 mg of L-arginine, 30 mg of zinc, 140 mcg of selenium, 200 IU (international units) of vitamin E, 120 mg of vitamin C, 10 mg of lycopene, 5,000 IU of vitamin A as beta-carotene, 800 mcg of folate, and 1,000 mcg of B12 ^[7]. Compare the current label with these numbers, because brands reformulate.

L-carnitine tartrate at 2,000 mg gives roughly 1,360 mg of L-carnitine. That covers about 68% of the 2 g dose in the Lenzi trial ^[6] and about four times what SIRE delivers. CoQ10 at 200 mg matches the Balercia dose ^[4]. NAC at 200 mg is a third of the 600 mg studied dose ^[5].

Zinc 30 mg and selenium 140 mcg stay under the 40 mg and 400 mcg upper limits ^[10][11]. The vitamin A comes from beta-carotene, which carries a lower toxicity risk than preformed vitamin A ^[12].

Study results. In men with abnormal semen, sperm DNA fragmentation fell from 43.5% to 34.3% after 3 months ^[7]. Concentration (sperm per milliliter), total and progressive motility, and sperm morphology, the share of normally shaped sperm, also improved ^[7]. Fairhaven reports a 38% rise in count and a 102% rise in progressive motility ^[18]. In 29 men with normal semen, only progressive motility improved ^[7].

The authors call it an internally controlled pilot, a small first study where men serve as their own comparison, with no pregnancy data ^[7]. “So FH PRO wins on evidence?” Not quite. Without a placebo arm, some change could come from men cutting alcohol or retesting at a better time. Proxeed Plus, reviewed below, has stronger trial design.

Pricing

As of November 2026, FH PRO costs $96.99 for 180 capsules, or 30 servings at $3.23 each ^[18]. A 90-day cycle costs $290.97. Fairhaven does not list a guarantee on the product page, so check its returns policy.

Shipping

Fairhaven makes FH PRO in the USA in a GMP-registered (Good Manufacturing Practice) facility ^[18]. Your cart shows shipping cost and delivery windows.

Where to buy

Fairhaven Health sells FH PRO directly, and Amazon and Walmart stock it too. See FH PRO on the official store.

If $97 a month stretches your budget, the next pick costs under a dollar a day.

Theralogix ConceptionXR Reproductive Health: Best budget pick

ConceptionXR Reproductive Health is a two-tablet antioxidant formula with vitamins C and E, zinc, selenium, and methylfolate ^[19]. It ranks fourth because one 180-tablet bottle covers a full 90-day sperm cycle for about $0.90 a day ^[19]. It suits men who want independently tested basics and plan to add CoQ10 only if a retest calls for it.

See the ConceptionXR Supplement Facts

Ingredient analysis

Vitamin C and vitamin E. Both neutralize free radicals in semen. Oxidative stress = a state where free radicals outnumber your antioxidant defenses and damage sperm membranes and DNA. The Cleveland Clinic review placed vitamins C and E among the five ingredients with the best published support ^[1]. Vitamin E is fat-soluble, so take the tablets with a meal.

Zinc and selenium. Zinc supports sperm production and helps run superoxide dismutase, an antioxidant enzyme, while selenium helps run glutathione peroxidase, another one ^[7]. Zinc also made the Cleveland Clinic’s top five ^[1]. The large folic acid and zinc trial found no live birth benefit ^[9], so do not expect zinc alone to change outcomes.

Methylfolate. Theralogix uses the methylated form ^[19]. Folate supports DNA copying in dividing sperm cells, though trial evidence for folate alone is weak ^[9].

The exact doses were not visible on the product page in November 2026. Read the Supplement Facts before you buy and check zinc against the 40 mg upper limit ^[10]. Theralogix also sells a separate ConceptionXR Motility Support formula ^[19].

Need CoQ10 too? Pairing ConceptionXR with two Thorne CoQ10 gelcaps costs about $2.67 a day, or $240 for 90 days, based on the prices in this article. That runs $90 more than SIRE on subscription and still leaves out NAC and carnitine.

Skip ConceptionXR if your semen analysis flags low motility as the main problem. The formula leaves out the two ingredients with the most motility data, CoQ10 ^[4] and carnitine ^[6]. It makes more sense for men with borderline count or morphology who want low-cost antioxidant coverage while they fix sleep, alcohol, and heat exposure.

Pricing

As of November 2026, Theralogix lists the 180-tablet bottle at $81.17 one-time, about $0.90 per serving at two tablets a day ^[19]. Theralogix also shows a lower subscription price. Check its site for the current rate and guarantee terms.

Shipping

Theralogix makes the formula in the USA in a cGMP-compliant (current Good Manufacturing Practice) facility ^[19]. Its product page skips shipping thresholds and delivery times.

Where to buy

Buy direct from Theralogix, or find it on Amazon and Walmart. Check ConceptionXR on the official store.

Hate swallowing pills? The next pick is a drink.

Proxeed Plus: Best pill-free formula

Proxeed Plus is a powder you dissolve in water twice a day, built on L-carnitine and acetyl-L-carnitine ^[20]. It has the strongest trial design on this list, with placebo-controlled studies on its own formula ^[8]. It ranks fifth because it costs $4.67 a day and delivers little CoQ10. It suits men who refuse capsules and whose results show low motility.

See Proxeed Plus details

Ingredient analysis

Each packet in the published trial contained 1 g of L-carnitine, 0.5 g of acetyl-L-carnitine, 0.725 g of fumarate (a salt form), 1 g of fructose, 50 mg of citric acid, 10 mg of zinc, 20 mg of CoQ10, 50 mcg of selenium, 90 mg of vitamin C, 200 mcg of folic acid, and 1.5 mcg of B12 ^[8]. Proxeed directs you to take two packets a day ^[20], which doubles every number.

“Why not take one packet and make the box last?” Because the trials gave men two packets a day ^[8]. Half the dose is a different product.

L-carnitine 2 g and acetyl-L-carnitine 1 g daily. These amounts match the Lenzi trial dose ^[6]. Acetyl-L-carnitine = a form of carnitine that also protects mitochondria from oxidative damage ^[8]. In a double-blind trial of 175 men with low count and motility, 6 months of Proxeed Plus raised progressive motility and vitality (the share of live sperm) and cut DNA fragmentation by a median 21% ^[8]. The placebo group showed no change ^[8].

The share of treated men with progressive motility above 20% rose from 61.6% to 73.4% ^[8]. A second placebo-controlled trial in 104 men found higher total count and progressive motility, with or without a varicocele, an enlarged vein in the scrotum ^[8].

Those gains are modest. But the placebo group stayed flat, and that comparison makes the result more credible than a before-and-after study.

CoQ10 at 40 mg daily is a fifth of the 200 mg Balercia dose ^[4]. Zinc at 20 mg and selenium at 100 mcg sit well under upper limits ^[10][11]. The trial placebo copied the formula’s inactive ingredients, including sucrose, so you take in sugar with every packet ^[8]. Each packet has 10 calories ^[20].

Pricing

As of November 2026, Proxeed lists one 30-packet box at $69.99 ^[20]. At two packets a day, that box lasts 15 days and costs $4.67 per day. A 90-day cycle needs six boxes, or $419.94. Amazon lists a subscribe-and-save price of $56.88 per box ^[22]. Proxeed’s site has the guarantee terms.

Shipping

Alfasigma USA distributes Proxeed in the United States ^[20]. Shipping cost and delivery windows show at checkout.

Where to buy

Buy from the official Proxeed store, or compare the Amazon subscription price. Check Proxeed Plus pricing.

If your semen analysis flags only motility, one ingredient may cover you.

Thorne CoQ10: Best single-ingredient add-on

Thorne CoQ10 is a 100 mg ubiquinone gelcap ^[21]. It ranks sixth because it covers one ingredient, but it is the simplest way to hit the studied CoQ10 dose. It suits men whose only flagged result is motility, or men adding CoQ10 to a basic formula like ConceptionXR.

See Thorne CoQ10 details

Ingredient analysis

CoQ10 (as ubiquinone), 100 mg per gelcap ^[21]. Ubiquinone = the standard form of CoQ10 sold in most supplements. Two gelcaps give you 200 mg, the dose that improved motility over placebo in 60 men across 6 months ^[4]. Three gelcaps reach 300 mg, the top of the 200 to 300 mg range used in studies ^[23]. CoQ10 is fat-soluble, so take it with a meal that contains some fat.

“Should I pay more for ubiquinol?” Ubiquinol = the reduced, ready-to-use form of CoQ10. In the Balercia trial, men took ubiquinone, and ubiquinol levels in their semen and sperm still rose ^[4]. Your body converts ubiquinone on its own. Spend the difference on reaching the full dose.

The Balercia trial measured motility, not DNA fragmentation. If fragmentation is your flagged result, the NAC data is more direct ^[5], so a full formula like SIRE I fits better.

Take 200 mg daily with your largest meal for 90 days, then repeat your semen analysis. If progressive motility has not moved, switching brands rarely helps. Bring both reports to a urologist, because persistent low motility can point to infection, a varicocele, or a hormone problem that no supplement fixes.

CoQ10 can cause mild stomach upset and may weaken warfarin, a blood thinner, so tell your doctor if you take it. Skip a single-ingredient plan if your results show count or morphology problems on top of low motility.

Pricing

As of November 2026, Thorne lists 60 gelcaps at $53.00, or $47.70 with a 10% subscription discount ^[21]. At 200 mg a day, one bottle lasts 30 days, which works out to $1.77 per day one-time or $1.59 on subscription. A 90-day cycle costs $159.00 one-time or $143.10 on subscription. Thorne’s product page does not show guarantee terms.

Shipping

Thorne’s product page listed no shipping threshold when I checked, so confirm cost and delivery time at checkout.

Where to buy

Buy from Thorne for the subscription discount, or find it at Amazon and Walmart. Check Thorne CoQ10 pricing.

Whichever of the best male fertility supplements you pick, book a semen analysis now and retest at 90 days. Without both numbers, you are guessing.

Frequently asked questions

Citations

^[1] Cleveland Clinic ConsultQD – “How Effective and Necessary Are Male Fertility Supplements?” – 2020 – based on Kuchakulla et al., Urology, PMID 31747549

^[2] Cochrane Database of Systematic Reviews – “Antioxidants for male subfertility” – 2022 – https://doi.org/10.1002/14651858.CD007411.pub5

^[3] Remembryo – “Study reviews 34 common male fertility sperm supplement brands for safety and efficacy” – 2023 – summary of de Ligny et al., PMC10244220

^[4] Fertility and Sterility – “Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia” – 2009 – PMID 18395716

^[5] Reproductive Biology and Endocrinology – “Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men” – 2019 – PMID 30771790

^[6] Fertility and Sterility – “A placebo-controlled double-blind randomized trial of the use of combined L-carnitine and L-acetyl-carnitine treatment in men with asthenozoospermia” – 2004 – PMID 15193480

^[7] Antioxidants – “Efficacy of Antioxidant Supplementation on Conventional and Advanced Sperm Function Tests in Patients with Idiopathic Male Infertility” – 2020 – https://doi.org/10.3390/antiox9030219

^[8] Andrologia – “Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia” – 2019 – PMC6850469

^[9] JAMA – “Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment” – 2020 – PMID 31910279

^[10] NIH Office of Dietary Supplements – “Zinc Health Professional Fact Sheet” – accessed November 2026

^[11] NIH Office of Dietary Supplements – “Selenium Health Professional Fact Sheet” – accessed November 2026

^[12] NIH Office of Dietary Supplements – “Vitamin A and Carotenoids Health Professional Fact Sheet” – accessed November 2026

^[13] Hera Fertility – “Male Preconception Supplements Your 2026 Fertility Guide” – 2026

^[14] Healthline – “10 Ways to Boost Male Fertility and Increase Sperm Count” – accessed November 2026

^[15] GoodRx Health – “10 Male Fertility Supplements That May Boost Odds of Conception” – accessed November 2026

^[16] SIRE – “SIRE I Fertility Support for Men product page and Supplement Facts” – accessed November 2026

^[17] Bird&Be – “Male Fertility Power Pack product page” – accessed November 2026

^[18] Fairhaven Health – “FH PRO Fertility Multivitamin for Men product page” – accessed November 2026

^[19] Theralogix – “ConceptionXR Reproductive Health Supplement product page” – accessed November 2026

^[20] Proxeed – “Proxeed Plus product page” – accessed November 2026

^[21] Thorne – “CoQ10 product page” – accessed November 2026

^[22] Amazon – “Proxeed Plus Male Fertility Supplement 30 Count listing” – accessed November 2026

^[23] BodySpec – “Best Male Fertility Supplements Evidence-Based Guide” – September 2025