What is NMN: Benefits, Side Effects, Dosage, Supplements (Science Based)
NMN, also known as nicotinamide mononucleotide, is a molecule that is found naturally in the body and plays a crucial role in the aging process. In this article, we will explore what is NMN, the potential benefits and side effects of it, as well as the appropriate dosage and the availability of NMN supplements.
It is thought to have numerous potential health benefits, including improving energy metabolism, reducing oxidative stress, and potentially slowing the aging process.
NMN supplements are now widely available and are being marketed as a way to potentially improve health and longevity.
However, it is important to understand the potential risks and benefits of NMN before considering using supplements.
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What is NMN (Nicotinamide mononucleotide)
NMN, or nicotinamide mononucleotide, is a molecule that is found naturally in the body and is involved in a number of important biological processes.
It is a derivative of niacin, also known as vitamin B3, and is involved in the production of nicotinamide adenine dinucleotide (NAD+), a coenzyme that plays a key role in energy metabolism.
NMN is synthesized in the body from nicotinamide riboside (NR), a form of vitamin B3. It is found in a variety of tissues, including the liver, pancreas, and muscles, and is thought to have numerous potential health benefits.
How NMN is produced in our bodies?
NMN is produced in the body through a process called salvage pathway. [1]
This pathway begins with the conversion of nicotinamide riboside (NR), a form of vitamin B3, into nicotinamide mononucleotide (NMN) by an enzyme called nicotinamide riboside kinase (NRK).
NMN is then converted into nicotinamide adenine dinucleotide (NAD+) by another enzyme called NMN adenylyl transferase (NMNAT). [2]
NAD+ is a coenzyme that plays a key role in energy metabolism and is involved in a variety of important biological processes, including DNA repair, gene expression, and the regulation of cellular metabolism.
It is important to note that the production of NMN in the body can be affected by a number of factors, including diet, age, and overall health. In particular, the levels of NMN in the body tend to decline with age, which is thought to contribute to the aging process.
Supplementation with NMN or other compounds that can increase the levels of NAD+ in the body, such as NR, is being explored as a way to potentially improve health and longevity.
However, more research is needed to fully understand the effects of NMN and other NAD+ precursors on the body and how they may affect the aging process.
NMN Benefits
NMN is thought to have numerous potential health benefits, although much of the research on NMN is still in the early stages and more studies are needed to fully understand its effects on the body.
Some of the potential benefits of NMN that have been suggested by research include:
Can Improve energy metabolism
NMN has been shown to improve energy metabolism in a number of studies. Energy metabolism refers to the process by which cells produce and use energy, and it is essential for the proper functioning of the body.
NMN is involved in the production of NAD+, a coenzyme that plays a key role in energy metabolism, and increasing the levels of NAD+ in the body has been shown to improve energy metabolism.
For example, one study found that NMN supplementation improved energy metabolism in mice with a genetic defect that caused a decline in NAD+ levels and led to a condition known as mitochondrial myopathy, a type of muscle disease. [3]
Another study found that NMN supplementation improved the physical activity and endurance of aged mice and increased the lifespan of mice with a genetic defect that caused a decline in NAD+ levels. [4]
Can Reduce Oxidative Stress
NMN has been shown to have antioxidant effects and may help to reduce oxidative stress in a number of studies.
Oxidative stress is a process that occurs when the body is exposed to too many free radicals, which are highly reactive molecules that can damage cells and contribute to the development of diseases such as cancer and cardiovascular disease.
For example, one study found that NMN supplementation reduced oxidative stress and improved the survival rate of mice exposed to oxidative stress. [5]
Another study found that NMN supplementation improved the antioxidant capacity of human cells and reduced the levels of markers of oxidative stress in the blood of human subjects. [6] [7]
Can slow down the aging process
NMN is thought to have anti-aging effects and may be able to slow the aging process, although more research is needed to fully understand the effects of NMN on aging and to determine whether it can truly slow the aging process.
The aging process is complex and is influenced by a number of factors, including genetics, diet, and environmental exposures.
Some studies have suggested that increasing the levels of NAD+ in the body through NMN supplementation may be able to slow the aging process by improving energy metabolism and reducing oxidative stress. [8]
However, more research is needed to confirm these findings and to determine whether NMN can slow the aging process in humans.
Can restore skeletal muscle
NMN supplementation has been shown to have beneficial effects on skeletal muscle in some studies. Skeletal muscle is responsible for movement and is found in the body’s extremities, such as the arms and legs.
Some studies have found that NMN supplementation can restore skeletal muscle function and improve physical performance in animals. For example, one study found that NMN supplementation partially reversed their skeletal muscle aging by restoration of normal NAD⁺ levels. [9]
Improves neuronal function in the brain
NMN has been shown to improve neuronal function in the brain. The brain is a highly metabolic organ, meaning that it requires a large amount of energy to function properly.
For example, one study found that NMN supplementation improved the cognitive function of mice with a genetic defect that caused a decline in NAD+ levels and led to a condition known as neurodegeneration, which is characterized by the progressive loss of nerve cells in the brain. [10]
Another study found that NMN supplementation improved the memory and learning ability of mice with Alzheimer’s disease. However, it is important to note that more research is needed to confirm these findings and to determine whether NMN can improve neuronal function in humans. [11]
Potential NMN Side Effects
NMN is generally considered to be safe when taken at recommended doses, and there have been no reported serious side effects of NMN supplementation in humans. However, like any supplement, NMN may cause side effects in some people, and it is important to be aware of the potential risks before taking NMN supplements.
Some of the potential side effects of NMN supplementation that have been reported in studies include:
- Digestive issues: Some people may experience digestive issues when taking NMN supplements, such as nausea, vomiting, and diarrhea.
- Skin irritation: NMN may cause skin irritation in some people, although this is rare.
- Allergic reactions: NMN may cause allergic reactions in some people, although this is rare. Symptoms of an allergic reaction may include rash, itching, swelling, and difficulty breathing.
It is important to note that the potential side effects of NMN supplementation are still being studied and more research is needed to fully understand the risks of NMN supplementation.
What is The Best NMN Supplement
Although the are hundreds of NMN supplements in the market as we speak, we took the time and picked some of the best selling NMN supplements on Amazon and online.
The following supplements are picked not solely by their number of reviews and sales but taking into consideration factors such as brand reputation and ingredients.
Anti-Aging Supplement NAD+ 11-Complex AEON (2500 mg)
The Anti-Aging Supplement NAD+ 11-Complex AEON is a blend of 11 different vitamins, minerals, and antioxidants designed to help you feel and look your best as you age.
The formula contains NAD+, which is a molecule that plays a crucial role in maintaining youthful energy levels and supporting healthy aging.
It also includes Fisetin, Quercetin, Resveratrol, along with coenzyme Q10, Epigallocatechin Gallate (EGCG), and Collagen, to support optimal cellular health and protect against oxidative stress.
TRU NIAGEN NAD+ Booster (300mg)
TRU NIAGEN is a multi award-winning, patented NAD+ booster supplement that is more efficient than NMN (nicotinamide mononucleotide) at supporting cellular energy metabolism and repair.
TRU NIAGEN is made with nicotinamide riboside (NR), a form of vitamin B3 that has been shown to be more effective at increasing the levels of NAD+ in the body compared to other NAD+ precursors such as NMN.
TRU NIAGEN is designed to support healthy aging and is formulated with 300mg of NR per serving (90ct/90 servings).
Codeage Liposomal NMN + Resveratrol 500mg
Codeage Liposomal NMN 500mg Supplement is a dietary supplement designed to support healthy aging, energy, and muscle metabolism.
The supplement contains 500mg of NMN (nicotinamide mononucleotide) per serving, as well as resveratrol, a compound found in red wine that has been shown to have antioxidant effects and may support healthy aging.
It also contains betaine anhydrous TMG (trimethyl-glycine), riboflavin, and vitamin B12, which are all involved in energy metabolism.
The supplement is formulated with a liposomal delivery system, which may help to improve the absorption of the active ingredients.
Genex Formulas NMN 250mg
NMN Nicotinamide Mononucleotide Supplement (250mg) from Genex Formulas is a dietary supplement designed to support healthy aging and DNA repair by increasing NAD (nicotinamide adenine dinucleotide) levels in the body.
Genex Formulas NMN Nicotinamide Mononucleotide Supplements are made with a stabilized form of NMN that is 99% pure and has been formulated for maximum stability and effectiveness.
The supplement comes in the form of capsules and is recommended to be taken as a dietary supplement, with 60 capsules per bottle (60 servings). Each serving contains 250mg of NMN.
partiQlar Pure NMN
If you’re looking for a way to boost your energy, endurance, and overall health, you might want to check out partiQlar Pure NMN capsules.
These capsules contain 500 mg of pure NMN, a molecule that supports NAD+ levels in your body. NAD+ is a key factor for many vital processes, such as DNA repair, insulin sensitivity, and brain function.
By taking NMN, you can replenish your NAD+ levels and enjoy the benefits of healthy aging.
Plus, partiQlar Pure NMN capsules are made in the USA, in GMP certified facilities, and have a 60-day money back guarantee.
You can also get free delivery in the US or internationally if you order more than $200.
And if you subscribe, you can save 10% on every order. So don’t wait, order your partiQlar Pure NMN capsules today and feel the difference!
NMN Dosage
The recommended dosage of NMN varies depending on the source and the intended use. Some sources recommend doses of 250-500 mg per day, while others suggest doses of up to 1,000 mg per day.
It is important to note that NMN is a relatively new supplement and there is a lack of scientific data on its safety and effectiveness. It is not yet known what the optimal dosage of NMN might be or whether it is safe to use in the long term.
It is always a good idea to talk to a healthcare provider before starting any new supplement, including NMN. They can help you understand the potential risks and benefits and determine whether NMN is appropriate for you.
Frequently Asked Questions
Bottom Line
NMN is a promising molecule that may have anti-aging effects and improve various aspects of health.
However, more research is needed to confirm its safety and efficacy in humans. If you are interested in trying NMN supplements, consult your doctor first and follow the recommended dosage.
You can also boost your NMN levels naturally by eating foods rich in NAD+ precursors, such as broccoli, cabbage, avocado, and mushrooms.
Remember that NMN is not a magic pill, and you should always combine it with a balanced diet and lifestyle for optimal wellness.
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